Cataract is a leading cause of treatable or avoidable blindness worldwide, particularly in older adults. While traditionally
considered an ocular pathology, emerging evidence indicates that systemic factors, including disturbances in
haemostasis, may contribute to cataract formation. This review systematically examines 15 clinical studies investigating
haemostatic parameters such as platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), and
fibrinogen levels in relation to cataractogenesis. Key findings indicate that elevated mean platelet volume (MPV),
shortened PT/aPTT, and increased plasma fibrinogen are associated with lens opacity. However, most studies are cross
sectional, heterogeneous in design, and vary in haemostatic measurement methods. Limitations include small sample
sizes and potential confounding from systemic diseases. Understanding the interplay between coagulation, inflammation,
oxidative stress, and ocular microcirculation may enhance early identification of patients at risk and inform preventive
strategies for cataract formation.

Keywords: Cataract, Haemostasis, Platelet count, Prothrombin time, Activated partial thromboplastin time, Fibrinogen,
Coagulation